Effects of an interdisciplinary intervention program on the grouping of cardiometabolic variables in adolescents with excessive weight

Abstract

The aim of the study was to invest igate changes in the characterist ics of grouping of cardiometabolic variables related to insulin resistance in response to an interdisciplinary intervention program in overweight adolescents. This study was performed in overweight adolescents, composed o f a cont rol group (n = 19) and an intervent ion group (n = 20), who part icipated in a six monthinterdisciplinary program. Body mass index, waist circumference, systolic and diastolic blood pressure were evaluated; blood collect ion for glucose, insulin and uric acid assessment and HOMA-IR index, before and after the program. An exploratory factorial analysis was performed through analy sis o f main components, and factorial loads associated with values ≥ 0.50 were considered. In the pre-intervention period, three factorial components explained the variability of the variables in bo th gro ups, an d the composition of the components was equal, where anthropometric and blood pressure variables comprised factor 1; the second component related to the variables related to insulin resistance, insulin and HOMAIR; and the third component was composed of glycemia and uric acid. Post-intervention, two components explained in both groups and the composition was distinct, and in the intervent io n gro up , in sul in an d HOMA-IR became part of factor 1; in the control group, glycemia was negatively correlated with the anthropometric and blood pressure indicators in component 1; and glycemia, insulin, HOMA-IR and ur ic acid were associated with factor 2. It was concluded that the intervention program promoted modification in the grouping of the cardiometabolic variables of obese adolescents, in which the insulin and HOMA-IR variables belonged to the factor 1. No central factor was found to explain the grouping of variables in an y of the analyzes, thus confirming the complex relationship between the analyzed variables.