Cutaneous manifestation of cryptococcosis in patient with acquired immunodeficiency syndrome (AIDS) - a case report

Amanda Almeida Albuquerque, Vitor Laerte Pinto Júnior, Márcia dos Santos Lazéra

Resumo


Cryptococcosis is a fungal infection caused by Cryptococcus neoformans encapsulated agent, being the variant gattii responsible for infection in immunocompetents and the variant grubii for infection in immunodeficients. C. neoformans infections have been increasingly recognized as a significant threat to the health of immune compromised populations throughout the world, especially in individuals with AIDS. The agent is acquired by inhalation, especially in immunocompromised the disease spreads through the hematogenic way affecting the central nervous system (CNS), skin, among other systems. Cutaneous manifestations occur in 10-15% of all cases of systemic cryptococcosis and is often associated with systemic infection. In this report we describe a case of a patient of 28 years, HIV positive, in which markedly cutaneous involvement provided the clinical suspicious of disseminated cryptococcosis, confirmed with analysis cerebrospinal fluid (CSF) and lesion histopathology analysis. Despite the recognition and correct treatment of the mycosis, the patient died after three days of hospital stay, reinforcing the severity of this condition and the need of clinical suspicious in the presence of typical cutaneous lesions.


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